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Jan 20 - Formulary Newsletter

    
13/01/2020
   
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Dec 19 – Drug Safety Update: Domperidone for nausea and vomiting lack of efficacy in children, reminder of contraindicatioins in adults and adolescents

    
08/01/2020
   
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Oct 19 - MHRA Drug Safety Update: Prescribing medicines in renal impairment using the appropriate estimate of renal function

    
08/01/2020
   
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Nov 19 - MHRA Drug Safety Update: Yellow fever vaccine: stronger precautions in people with weakened immunity and in those aged 60 years or older

    
24/12/2019
   
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Nov 19 - MHRA Drug Safety Update: Carfilzomib (Kyprolis▼): risk of reactivation of hepatitis B virus

    
24/12/2019
   
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October 19 - MHRA Drug Safety Update: Adrenaline auto-injectors: recent action taken to support safety

    
21/10/2019
   
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October 19 - MHRA Drug Safety Update: Nivolumab (Opdivo): reports of cytomegalovirus (CMV) gastrointestinal infection or reactivation

    
21/10/2019
   
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October 19 - MHRA Drug Safety Update: Ingenol mebutate gel (Picato ▼): increased incidence of skin tumours seen in some clinical studies

    
21/10/2019
   
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September 19 - MHRA Drug Safety Update: Hormone replacement therapy (HRT): further information on the known increased risk of breast cancer with HRT and its persistence after stopping

    
08/10/2019
   
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September 19 - MHRA Drug Safety Update: Fingolimod (Gilenya▼): increased risk of congenital malformations; new contraindication during pregnancy and in women of childbearing potential not using effective contraception

    
08/10/2019
   
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September 19 - MHRA Drug Safety Update: Elmiron (pentosan polysulfate sodium): rare risk of pigmentary maculopathy

    
08/10/2019
   
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September 19 - MHRA Drug Safety Update: Montelukast (Singulair): reminder of the risk of neuropsychiatric reactions

    
08/10/2019
   
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August 19 - MHRA Drug Safety Update: Carfilzomib (Kyprolis▼): reminder of risk of potentially fatal cardiac events

    
20/08/2019
   
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August 19 - MHRA Drug Safety Update: Naltrexone/bupropion (Mysimba▼): risk of adverse reactions that could affect ability to drive

    
20/08/2019
   
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August 19 - MHRA Drug Safety Update: Daratumumab (Darzalex▼): risk of reactivation of hepatitis B virus

    
20/08/2019
   
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July 19 - MHRA Drug Safety Update: Rivaroxaban (Xarelto▼): reminder that 15mg and 20mg tablets should be taken with food

    
18/07/2019
   
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July 19 - MHRA Drug Safety Update: Tocilizumab (RoActemra): rare risk of serious liver injury including cases requiring transplantation

    
18/07/2019
   
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July 19 - MHRA Drug Safety Update: Febuxostat (Adenuric): increased risk of cardiovascular death and all-cause mortality in clinical trial in patients with a history of major cardiovascular disease

    
18/07/2019
   
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June 19 - MHRA Drug Safety Update: Oral retinoid medicines▼: revised and simplified pregnancy prevention educational materials for healthcare professionals and women

    
03/07/2019
   
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June 19 - MHRA Drug Safety Update: Lartruvo▼ (olaratumab): withdrawal of the EU marketing authorisation due to lack of efficacy

    
03/07/2019
   
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June 19 - MHRA Drug Safety Update: GLP-1 receptor agonists: reports of diabetic ketoacidosis when concomitant insulin was rapidly reduced or discontinued

    
03/07/2019
   
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June 19 - MHRA Drug Safety Update: Direct-acting oral anticoagulants (DOACs): increased risk of recurrent thrombotic events in patients with antiphospholipid syndrome

    
03/07/2019
   
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May 19 - MHRA Drug Safety Update: Magnesium sulfate: risk of skeletal adverse effects in the neonate following prolonged or repeated use in pregnancy

    
03/07/2019
   
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May 19 - MHRA Drug Safety Update: Tofacitinib (Xeljanz▼): restriction of 10 mg twice-daily dose in patients at high risk of pulmonary embolism while safety review is ongoing

    
03/07/2019
   
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May 19 - MHRA Drug Safety Update: Lemtrada (alemtuzumab) and serious cardiovascular and immune-mediated adverse reactions: new restrictions to use and strengthened monitoring requirements

    
03/07/2019
   
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April 19 - MHRA Drug Safety Update: Elvitegravir boosted with cobicistat: avoid use in pregnancy due to risk of treatment failure and maternal-to-child transmission of HIV-1

    
03/07/2019
   
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April 19 - MHRA Drug Safety Upate: Pregabalin (Lyrica), gabapentin (Neurontin) and risk of abuse and dependence: new scheduling requirements from 1 April

    
03/07/2019
   
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April 19 - MHRA Drug Safety Update: Belimumab (Benlysta▼): increased risk of serious psychiatric events seen in clinical trials

    
03/07/2019
   
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April 19 - MHRA Drug Safety Update: Valproate medicines and serious harms in pregnancy: new Annual Risk Acknowledgement Form and clinical guidance from professional bodies to support compliance with the Pregnancy Prevention Programme

    
03/07/2019
   
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April 19 -  MHRA Drug Safety Update: Yellow fever vaccine (Stamaril) and fatal adverse reactions: extreme caution needed in people who may be immunosuppressed and those 60 years and older

    
03/07/2019
   
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April 19 - Formulary Newsletter: Buckinghamshire Joint Formulary Newsletter April 2019

    
30/04/2019
   
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March 19 - MHRA Drug Safety Update: Onivyde (irinotecan, liposomal formulations): reports of serious and fatal thromboembolic events

    
08/04/2019
   
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March 19 - MHRA Drug Safety Update: Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects

    
26/03/2019
   
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February 19 - MHRA Drug Safety Update:  SGLT2 inhibitors: reports of Fournier's gangrene (necrotising fasciitis of the genitalia or perineum)

    
18/02/2019
   
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February 19 - MHRA Drug Safety Update:  Carbimazole: risk of acute pancreatitis

    
18/02/2019
   
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February 19 - MHRA Drug Safety Update: Carbimazole: increased risk of congenital malformations;strengthened advice on contraception

    
18/02/2019
   
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January 19  - MHRA Drug Safety Update:  Ipilimumab (Yervoy): reports of cytomegalovirus (CMV) gastrointestinal infection or reactivation

    
15/01/2019
   
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January 19 - MHRA Drug Safety Update:  Tapentadol (Palexia): risk of seizures and reports of serotonin syndrome when co-administered with other medicines

    
15/01/2019
   
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December 18 - MHRA Drug Safety Update:  Oral lidocaine-containing products for infant teething: only to be available under the supervision of a pharmacist

    
13/12/2018
   
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November 18 - MHRA Drug Safety Update:  Sildenafil (Revatio and Viagra): reports of persistent pulmonary hypertension of the newborn (PPHN) following in-utero exposure in a clinical trial on intrauterine growth restriction

    
15/11/2018
   
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November 18 - MHRA Drug Safety Update:  Systemic and inhaled fluoroquinolones: small increased risk of aortic aneurysm and dissection; advice for prescribing in high-risk patients

    
15/11/2018
   
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November 18 - MHRA Drug Safety Update:  Hydrochlorothiazide: risk of non-melanoma skin cancer, particularly in long-term use

    
15/11/2018
   
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October 18 - MHRA Drug Safety Update: Transdermal fentanyl patches: life-threatening and fatal opioid toxicity from accidental exposure, particularly in children

    
12/10/2018
   
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October 18 - MHRA Drug Safety Update:  Ponatinib (Iclusig▼): reports of posterior reversible encephalopathy syndrome

    
12/10/2018
   
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October 18 - MHRA Drug Safety Update:  Ritonavir-containing products: reports of interaction with levothyroxine leading to reduced thyroxine levels

    
12/10/2018
   
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October 18 - MHRA Drug Safety Update:  Rivaroxaban (Xarelto▼) after transcatheter aortic valve replacement: increase in all-cause mortality, thromboembolic and bleeding events in a clinical trial

    
12/10/2018
   
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September 18 - MHRA Drug Safety Update:  Daclizumab beta (Zinbryta▼): risk of immune-mediated encephalitis – some cases several months after stopping treatment

    
04/10/2018
   
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September 18 - MHRA Drug Safety Update:  Xofigo▼ (radium-223-dichloride): new restrictions on use due to increased risk of fracture and trend for increased mortality seen in clinical trial

    
04/10/2018
   
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August 18 - MHRA Drug Safety Update:  Esmya (ulipristal acetate) and risk of serious liver injury: new restrictions to use and requirements for liver function monitoring before, during, and after treatment

    
28/08/2018
   
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July 18 - MHRA Drug Safety Update: Parenteral amphotericin B: reminder of risk of potentially fatal adverse reaction if formulations confused

    
24/07/2018
   
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July 18 - MHRA Drug Safety Update: Eltrombopag (Revolade): reports of interference with bilirubin and creatinine test results

    
24/07/2018
   
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July 18 - MHRA Drug Safety Update: Pressurised metered dose inhalers (pMDI): risk of airway obstruction from aspiration of loose objects

    
24/07/2018
   
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July 18 - MHRA Drug Safety Update: Darunavir boosted with cobicistat: avoid use in pregnancy due to risk of treatment failure and maternal-to-child transmission of HIV-1

    
24/07/2018
   
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June 18 - MHRA Drug Safety Update: Dolutegravir (Tivicay▼, Triumeq▼, Juluca▼): signal of increased risk of neural tube defects; do not prescribe to women seeking to become pregnant ; exclude pregnancy before initiation and advise use of effective contraception. 

    
25/06/2018
   
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June 18 - MHRA Drug Safety Update:  Denosumab (Xgeva▼) for giant cell tumour of bone: risk of clinically significant hypercalcaemia following discontinuation

    
25/06/2018
   
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June 18 - MHRA Drug Safety Update:  Denosumab (Xgeva▼)  for advanced malignancies involving bone: study data show new primary malignancies reported more frequently compared to zoledronate.

    
25/06/2018
   
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May 18 - MHRA Drug Safety Update: Braltus (tiotropium): risk of inhalation of capsule if placed in the mouthpiece of the inhaler

    
25/05/2018
   
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May 18 - MHRA Drug Safety Update: Valproate medicines (Epilim▼, Depakote▼): Pregnancy Prevention Programme materials online

    
25/05/2018
   
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April 18 - MHRA Drug Safety Update:  Obeticholic acid (Ocaliva▼): risk of serious liver injury in patients with pre-existing moderate or severe hepatic impairment; reminder to adjust dosing according to liver function monitoring.

    
24/04/2018
   
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April 18 - MHRA Drug Safety Update: Valproate medicines (Epilim▼, Depakote▼): contraindicated in women and girls of childbearing potential unless conditions of Pregnancy Prevention Programme are met.

    
24/04/2018
   
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March 18 - MHRA Drug Safety Update:  Daclizumab (Zinbryta▼): suspension and recall for safety reasons; review patients as soon as possible and start alternative therapy

    
13/03/2018
   
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March 18 - MHRA Drug Safety Update: Head lice eradication products: risk of serious burns if treated hair is exposed to open flames or other sources of ignition, eg, cigarettes

    
13/03/2018
   
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March 18 - MHRA Drug Safety Update:  Esmya (ulipristal acetate) for uterine fibroids: do not initiate or re-start treatment; monitor liver function in current or recent users

    
13/03/2018
   
news February 18 - MHRA Drug Safety Update: Gadolinium-containing contrast agents: Omniscan and iv Magnevist no longer authorised, MultiHance and Primovist for use only in liver imaging    
08/02/2018
   
news February 18 - MHRA Drug Safety Update: Mycophenolate mofetil, mycophenolic acid: updated contraception advice for male patients    
08/02/2018
   
news February 18 - MHRA Drug Safety Update: Misoprostol vaginal delivery system (Mysodelle): reports of excessive uterine contractions (tachysystole) unresponsive to tocolytic treatment    
08/02/2018
   
news January 18 - MHRA Drug Safety Update: Daclizumab (Zinbryta▼) and risk of severe liver injury: new restrictions to use and strengthened liver monitoring    
18/01/2018
   
news January 18 - MHRA Drug Safety Update: Recombinant human erythropoietins: very rare risk of severe cutaneous adverse reactions (SCARs)    
18/01/2018
   
news December 17 - MHRA Drug Safety Update: Fingolimod (Gilenya▼): updated advice about risk of cancers and serious infections    
20/12/2017
   
news December 17 - MHRA Drug Safety Update: Fingolimod (Gilenya▼): new contraindications in relation to cardiac risk    
20/12/2017
   
news December 17 - MHRA Drug Safety Update: Eluxadoline (Truberzi▼): risk of pancreatitis; do not use in patients who have undergone cholecystectomy or in those with biliary disorders    
20/12/2017
   
news December 17 - MHRA Drug Safety Update: Radium-223 dichloride (Xofigo▼): do not use in combination with abiraterone and prednisone/prednisolone, following clinical trial signal of increased risk of death and fractures    
20/12/2017
   
news December 17 - MHRA Drug Safety Update: Cladribine (Litak, Leustat) for leukaemia: reports of progressive multifocal encephalopathy (PML); stop treatment if PML suspected    
20/12/2017
   
news December 17 - MHRA Drug Safety Update: Gadolinium-containing contrast agents: removal of Omniscan and iv Magnevist, restrictions to the use of other linear agents    
20/12/2017
   
news November 17 - MHRA Drug Safety Update: Gentamicin: potential for histamine-related adverse drug reactions with some batches    
19/12/2017
   
news November 17 - MHRA Drug Safety Update: Quinine: reminder of dose-dependent QT-prolonging effects; updated medicine interactions    
19/12/2017
   
news November 17 - MHRA Drug Safety Update: Oral tacrolimus products: reminder to prescribe and dispense by brand name only    
19/12/2017
   
news November 17 - MHRA Drug Safety Update: Antiepileptic drugs: updated advice on switching between different manufacturers’ products    
19/12/2017
   
news October 17 - MHRA Drug Safety Update: Isotretinoin (Roaccutane): rare reports of erectile dysfunction and decreased libido    
19/12/2017
   
news October 17 - MHRA Drug Safety Update: Gabapentin (Neurontin): risk of severe respiratory depression    
19/12/2017
   
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October 17 - MHRA Drug Safety Update:  Clozapine: reminder of potentially fatal risk of intestinal obstruction, faecal impaction, and paralytic ileus

    
19/12/2017
   
news October 17 - MHRA Drug Safety Update: Methylprednisolone injectable medicine containing lactose (Solu-Medrone 40 mg): do not use in patients with cows’ milk allergy    
19/12/2017
   
news March 17 - Formulary Newsletter: Buckinghamshire Joint Formulary Newsletter March 2017    
30/11/2017
   

 

 

 

 


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